Founded on September 25, 1967, Psychodelic Reaction made a historical performance during a music contest at the Sparrendaal College in Vught, the Netherlands, where the group received a prize for their composition "Annette."
Before this band was formed, several members of the group had been associated with schoolbands such as (for insiders),
- The Vicals (1965) : negro-spirituals
- The Rascals / The New Rascals (1966) : negro-spirituals and covers
- System 3 (1967) : negro-spirituals, covers and own songs

Psychodelic Reaction performed covers of underground bands and a few songs of their own.

Melodia Melancholica